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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Composition :

DOLUTEGRAVIR-50MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIRETROVIRAL AGENTS

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - XAP0002

Author Details

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FAQs

Xapavir 50 Tablet works by decreasing the amount of HIV in the blood. It also increases the count of CD4 cells, a type of white blood cells that help the body to fight infection.

Antacids used to treat heartburn or indigestion, multivitamins, calcium or iron supplements may stop the absorption of Xapavir 50 Tablet and make it less effective. Therefore, do not take antacid, multivitamins, calcium or iron supplements 6 hours before and 2 hours after taking Xapavir 50 Tablet . However, consult the doctor before taking other medicines while on treatment with Xapavir 50 Tablet .

Few people taking combination therapy for HIV may develop osteonecrosis. Consult the doctor if you experience symptoms of osteonecrosis, such as stiffness in the joints, joint pain or aches, and difficulty moving.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Consult your doctor

It is not known whether Xapavir 50 Tablet interacts with alcohol. Please consult your doctor.

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Pregnancy

Caution

Xapavir 50 Tablet may increase the risk of birth defects. Please consult the doctor if you are pregnant. Your doctor will weigh the benefits and potential risks before prescribing Xapavir 50 Tablet .

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Xapavir 50 Tablet . HIV-positive women must not breastfeed as HIV infection can be passed to the baby in breast milk.

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Driving

Caution

Xapavir 50 Tablet may cause dizziness. Drive or operate machinery only if you are alert.

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Liver

Consult your doctor

Limited information is available. Please consult your doctor if you have liver problems. Your doctor will weigh the benefits and potential risks before prescribing Xapavir 50 Tablet .

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Kidney

Consult your doctor

Limited information is available. Please consult your doctor if you have kidney problems. Your doctor will weigh the benefits and potential risks before prescribing Xapavir 50 Tablet .

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Children

Caution

Please consult the doctor if you have any concerns regarding the usage of Xapavir 50 Tablet in children.

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Heart

Inform your doctor if you have any heart problems before using Xapavir 50 Tablet .

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Geriatrics

Consult your doctor

Xapavir 50 Tablet is generally safe in older adults, but they may be more prone to side effects such as tooth staining and altered taste. Please consult a doctor if you have any concerns.

About Xapavir 50 Tablet

Xapavir 50 Tablet belongs to a group of antiretroviral medicines called HIV integrase inhibitors indicated for the treatment of HIV infection. Xapavir 50 Tablet does not cure HIV infection. It reduces the viral load in the body and keeps it at a low level. Taking Xapavir 50 Tablet decreases the chance of developing AIDS (acquired immunodeficiency syndrome) and HIV-related illnesses such as cancer or serious infections.
 
Xapavir 50 Tablet contains Dolutegravir, which works by decreasing the amount of HIV in the blood. It also increases the count of CD4 cells, a type of white blood cells that help the body fight infection.
 
In some cases, Xapavir 50 Tablet may cause side effects such as nausea, vomiting, headache, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually. However, you are advised to talk to the doctor if the side effects persist or worsen.

Pregnancy testing should be performed in adolescents and adults of reproductive potential prior to starting Dolutegravir to rule out the use of Dolutegravir during the first trimester of pregnancy. Advise adolescents and adults with reproductive potential to take effective contraception on a regular basis. Avoid breastfeeding whilst on treatment with Xapavir 50 Tablet . Xapavir 50 Tablet may cause dizziness, so drive only if you are alert. Keep your doctor informed about your health condition and medications to prevent side effects/interactions.

Uses of Xapavir 50 Tablet

HIV infection

Medicinal Benefits Mweb

Medicinal Benefits

Xapavir 50 Tablet contains Dolutegravir, which belongs to a group of antiretroviral medicines indicated for the treatment of HIV infection. Xapavir 50 Tablet reduces the viral load in the body and keeps it at a low level. It also increases the count of CD4 cells, a type of white blood cells that help the body fight infection.

Directions for Use

Take Xapavir 50 Tablet with or without food. Swallow it as a whole with water; do not chew or crush it.

Side Effects of Xapavir 50 Tablet

  • Nausea
  • Vomiting
  • Headache
  • Diarrhoea
  • Abdominal pain or discomfort
  • Dizziness
  • Fatigue
  • Flatulence (wind)

Drug Warnings

Do not take Xapavir 50 Tablet if you are allergic to any of its components or if you are taking fampridine (used in multiple sclerosis) or dofetilide (used to treat heart conditions). Inform your doctor if you notice joint pain, bone problems, and stiffness or symptoms of infection/inflammation, such as fever, headache, stomach ache, and difficulty breathing. Let the doctor know if you are taking prescription/non-prescription medicines, including herbal products or supplements.

Drug-Drug Interactions

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DolutegravirDofetilide
Critical

Drug-Drug Interactions

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DolutegravirDofetilide
Critical
How does the drug interact with Xapavir 50 Tablet:
Taking Xapavir 50 Tablet with dofetilide may possibly reduce the blood levels and effects of Xapavir 50 Tablet. This can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Xapavir 50 Tablet with Dofetilide is not recommended, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Xapavir 50 Tablet:
Co-administration of Sodium bicarbonate and Xapavir 50 Tablet reduces the levels of Xapavir 50 Tablet, resulting in reduced effectiveness.

How to manage the interaction:
Although taking Xapavir 50 Tablet and Sodium bicarbonate together can result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience symptoms like fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, and pain or burning during urination, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Xapavir 50 Tablet:
Taking Xapavir 50 Tablet with oxcarbazepine may significantly decrease Xapavir 50 Tablet blood levels, making the medicine less effective in treating infection.

How to manage the interaction:
Although taking oxcarbazepine and Xapavir 50 Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. Do not discontinue using any medications without consulting a doctor.
How does the drug interact with Xapavir 50 Tablet:
Taking Xapavir 50 Tablet with magnesium sulfate can reduce the effects of Xapavir 50 Tablet.

How to manage the interaction:
Although taking Xapavir 50 Tablet and Magnesium sulfate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if your condition gets worse or if you develop new infections while taking these medications, it is important to contact a doctor immediately. Do not discontinue using any medications without consulting a doctor.
DolutegravirAttapulgite
Severe
How does the drug interact with Xapavir 50 Tablet:
Taking Xapavir 50 Tablet with Attapulgite can reduce the effectiveness of Xapavir 50 Tablet.

How to manage the interaction:
Taking Xapavir 50 Tablet with Attapulgite together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is recommended to take Xapavir 50 Tablet at least two hours before or six hours after the attapulgite dose. Do not discontinue using any medications without consulting a doctor.
How does the drug interact with Xapavir 50 Tablet:
Taking Xapavir 50 Tablet with phenytoin may significantly reduce the blood levels of Xapavir 50 Tablet, which may make the medication less effective in treating infections.

How to manage the interaction:
Although taking Xapavir 50 Tablet and Phenytoin together can result in an interaction, they can be taken together if prescribed by a doctor. Do not discontinue using any medications without consulting a doctor.
How does the drug interact with Xapavir 50 Tablet:
Co-administration of Xapavir 50 Tablet and Calcium gluconate may interfere with the absorption of Xapavir 50 Tablet and reduce its effectiveness.

How to manage the interaction:
Although there is an interaction, Calcium gluconate can be taken with Xapavir 50 Tablet if prescribed by the doctor. However, take Xapavir 50 Tablet 2 hours before or 6 hours after taking calcium gluconate. Do not stop using any medications without talking to a doctor.
DolutegravirFerric maltol
Severe
How does the drug interact with Xapavir 50 Tablet:
Taking Xapavir 50 Tablet with ferric maltol can reduce the effectiveness of Xapavir 50 Tablet.

How to manage the interaction:
Although taking Xapavir 50 Tablet and Ferric maltol together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Xapavir 50 Tablet either two hours before or six hours after taking a dose of Ferric maltol. Do not discontinue using any medications without consulting a doctor.
DolutegravirFosphenytoin
Severe
How does the drug interact with Xapavir 50 Tablet:
Taking Xapavir 50 Tablet with fosphenytoin can reduce the effectiveness of Xapavir 50 Tablet.

How to manage the interaction:
Although taking Xapavir 50 Tablet and Fosphenytoin together can result in an interaction, they can be taken together if prescribed by your doctor. Do not discontinue using any medications without consulting a doctor.
DolutegravirCalcium glubionate
Severe
How does the drug interact with Xapavir 50 Tablet:
Co-administration of Xapavir 50 Tablet with Calcium glubionate can reduce the effectiveness of Xapavir 50 Tablet.

How to manage the interaction:
Taking Xapavir 50 Tablet with Calcium glubionate together can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, take Xapavir 50 Tablet at least two hours before or six hours after calcium citrate. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • METFORMIN
  • RIFAMPICIN
  • PHENYTOIN
  • PHENOBARBITAL
  • OXCARBAZEPINE
  • CARBAMAZEPINE
  • St John's wort

Habit Forming

No

Special Advise

  • During HIV therapy, there may be weight gain, and increase in blood lipids and blood glucose levels. Regular monitoring is advised.
  • Discuss with your doctor about effective birth control methods that you can use during your treatment. 

Diet & Lifestyle Advise

  • Practise safe sex by using condoms; it helps in reducing contact with semen and vaginal fluids.
  • Never share personal items that can have body fluids or blood on them, such as razor blades or toothbrushes.
  • Avoid sharing used needles, other injections or drug equipment.
  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food, vegetables and fruits as it helps to boost your immune system. Opt for lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods. Avoid spicy or oily foods if you experience nausea or vomiting.
  • Try to reduce emotional and physical stress by spending time with family or doing whatever makes you happy.

Xapavir 50 Tablet Substitute

Medicine Composition:

DOLUTEGRAVIR-50MG

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