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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Composition :

GOLIMUMAB-50MG

Manufacturer/Marketer :

Johnson & Johnson Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Therapeutic Class

IMMUNOSUPPRESSANTS

Country of origin

Switzerland
Other Info - SI17953

FAQs

Simponi 50mg Injection contains Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive.

Simponi 50mg Injection affects your immune system and makes you more susceptible to infections. It is not recommended in people with active infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, or weak immune system. Hence, inform your doctor if you have any history of these conditions beforehand.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

It is not known if alcohol interacts with Simponi 50mg Injection. Please consult the doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before receiving Simponi 50mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is not known whether Simponi 50mg Injection passes into human milk. Hence, if you are breastfeeding, inform your doctor before receiving Simponi 50mg Injection.

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Driving

Caution

Simponi 50mg Injection will be administered in the hospital setting. Hence, driving is not recommended.

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Liver

Caution

Simponi 50mg Injection may cause liver disease. Inform your doctor if you have a poor appetite, yellow discolouration of the skin or eyes, and abdominal pain. If you have pre-existing or a history of liver problems, let your doctor know, as this medicine may worsen your condition.

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Kidney

Consult your doctor

Limited data on the effects of Simponi 50mg Injection in patients with kidney impairment is available. If you have a pre-existing or a history of kidney disease, inform your doctor before taking Simponi 50mg Injection.

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Children

Unsafe

Simponi 50mg Injection is not recommended for use in children below 18 years of age as safety and efficacy are not established.

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Heart

Inform your doctor if you have heart disease before using Simponi 50mg Injection. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Caution

Simponi 50mg Injection may require dose adjustment in elderly patients based on their condition and medical requirements.

About Simponi 50mg Injection

Simponi 50mg Injection belongs to the Anti-monoclonal TNF (Tumor necrosis factor) class of medicines that help reduce signs and symptoms of autoimmune disorders. It is primarily used in the treatment of moderate to severe rheumatoid arthritis, active ankylosing spondylitis, active ulcerative colitis, and active psoriatic arthritis in adult patients. This medicine is used in combination with methotrexate for the treatment of autoimmune disorders.

Simponi 50mg Injection consists of Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

Simponi 50mg Injection may cause certain side effects such as nausea, headache, upper respiratory tract infections, dizziness, constipation, rash, and injection site reactions. Most of these side effects do not require medical attention or resolve over time. However, if these side effects persist for longer, please consult your doctor. A trained healthcare doctor will administer Simponi 50mg Injection. Hence, do not self-administer. Your physician will decide the dose and duration of the medicine based on the type and severity of the condition.

Simponi 50mg Injection should be avoided if you are allergic to any of its components. Inform your doctor if you have any history of serious infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Simponi 50mg Injection may cause dizziness, so drive only if you are alert and focused. Simponi 50mg Injection is not recommended for use in children below 18 years of age as safety has not been established. If you are pregnant or breastfeeding, consult your doctor before taking Simponi 50mg Injection.

Uses of Simponi 50mg Injection

Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, and Ulcerative colitis.

Medicinal Benefits Mweb

Medicinal Benefits

Simponi 50mg Injection contains Golimumab, as an active ingredient that belongs to the class of monoclonal TNF inhibitors. It works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation, pain and redness caused by various autoimmune diseases.

Directions for Use

Simponi 50mg Injection will be administered by a healthcare professional. Do not self-administer.

Side Effects of Simponi 50mg Injection

  • Tingling or numbness
  • Injection site reactions
  • Headache
  • Nausea
  • Upper respiratory tract infections.
  • Dizziness
  • Constipation
  • Rash

Drug Warnings

Simponi 50mg Injection should be avoided if you are allergic to any of its components.  Inform your doctor if you have any history of serious infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, blood disorders, nervous system problems, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Simponi 50mg Injection may cause dizziness, so drive only if you are alert and focused. Simponi 50mg Injection is not recommended for use in children below 18 years of age as safety has not been established. It is not known whether Simponi 50mg Injection can be given to pregnant and breastfeeding women. Hence, consult your doctor if you are pregnant, planning to become pregnant or are breastfeeding. Do not take live vaccines while being treated with Simponi 50mg Injection to prevent any serious consequences.

Drug-Drug Interactions

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GolimumabImatinib
Severe
Severe

Drug-Drug Interactions

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GolimumabImatinib
Severe
How does the drug interact with Simponi 50mg Injection:
When Imatinib is taken with Simponi 50mg Injection, it can increase the risk of developing serious infections.

How to manage the interaction:
Taking Imatinib with Simponi 50mg Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
Severe
How does the drug interact with Simponi 50mg Injection:
Co-administration of Mercaptopurine with Simponi 50mg Injection together can increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Mercaptopurine and Simponi 50mg Injection, but it can be taken if prescribed by a doctor. If you have any of these symptoms, contact a doctor right away. These symptoms include fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not discontinue any medications without consulting a doctor.
GolimumabPrednisolone
Severe
How does the drug interact with Simponi 50mg Injection:
Co-administration of Simponi 50mg Injection with Prednisolone could increase the risk of severe infections.

How to manage the interaction:
Although taking Simponi 50mg Injection with Prednisolone together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor immediately if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in the coughing fluid, weight loss, red or irritated skin, body sores, or discomfort or burning when urinating. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Simponi 50mg Injection:
Taking Mycophenolic acid and Simponi 50mg Injection can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
There could be a possible interaction between Mycophenolic acid and Simponi 50mg Injection, but they can be taken together if your doctor has prescribed them. However, if you experience fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination consult a doctor. Do not discontinue any medications without a doctor's advice.
GolimumabBosutinib
Severe
How does the drug interact with Simponi 50mg Injection:
Coadministration of bosutinib and Simponi 50mg Injection may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction between Bosutinib and Simponi 50mg Injection, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Simponi 50mg Injection:
Hydroxycarbamide when used with Simponi 50mg Injection may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between hydroxycarbamide with Simponi 50mg Injection, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
GolimumabMelphalan
Severe
How does the drug interact with Simponi 50mg Injection:
Co-administration of Melphalan with Simponi 50mg Injection together can increase the risk of infection.

How to manage the interaction:
Co-administration of Melphalan with Simponi 50mg Injection can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
GolimumabDeflazacort
Severe
How does the drug interact with Simponi 50mg Injection:
Simponi 50mg Injection can cause tendinitis (inflammation of the thick fibrous cords that attach muscle to bone) and tendon rupture (injury to the soft tissue that connect muscle to bone), and the risk may be increased when combined with other drugs such as deflazacort.

How to manage the interaction:
Although there is an interaction, Simponi 50mg Injection can be taken with deflazacort if prescribed by the doctor. However, if you experience pain, swelling at the back of the ankle, biceps, shoulder, hand, or thumb, consult a doctor immediately. Avoid exercise or use of the affected area until further instruction from your doctor. Do not stop using any medications without first talking to your doctor.
GolimumabIbrutinib
Severe
How does the drug interact with Simponi 50mg Injection:
Co-administration of Ibrutinib and Simponi 50mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Ibrutinib can be taken with Simponi 50mg Injection, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
GolimumabMitomycin
Severe
How does the drug interact with Simponi 50mg Injection:
Using mitomycin together with Simponi 50mg Injection may increase the risk of serious infections.

How to manage the interaction:
Although taking Mitomycin and Simponi 50mg Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination call your doctor right away. Do not discontinue any medications without first consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Habit Forming

No

Special Advise

  • It is advised to closely monitor the patient for the development of any active infections during and after the treatment.
  • It is essential to inform your doctor if you have any active viral, bacterial, and fungal infections before starting Simponi 50mg Injection.

Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching that is less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid freezing and hot temperatures.
  • Avoid wearing tight-fitting clothes; instead, wear loose garments.
  • Rest well and get plenty of sleep.
  • Stay hydrated; drink plenty of water.

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