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MISCELLANEOUS

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Drug-Drug Interactions

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LidocaineArbutamine
Critical
LidocaineSaquinavir
Critical

Drug-Drug Interactions

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LidocaineArbutamine
Critical
How does the drug interact with Dologel 15 gm:
Taking Dologel 15 gm and Arbutamine together can affect the rhythm of your heart.

How to manage the interaction:
Taking Dologel 15 gm with arbutamine is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience irregular heartbeat, chest tightness, blurred vision and nausea. Do not discontinue any medication without consulting a doctor.
LidocaineSaquinavir
Critical
How does the drug interact with Dologel 15 gm:
Taking Dologel 15 gm with Saquinavir can increase the blood levels of Dologel 15 gm and cause an irregular heart rhythm.

How to manage the interaction:
Taking Dologel 15 gm with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting and rapid heartbeat. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dologel 15 gm:
Taking Dologel 15 gm with hydroxycarbamide can increase the risk of methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking hydroxycarbamide and Dologel 15 gm together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dologel 15 gm:
Taking Dologel 15 gm with Phenytoin may increase the risk of methemoglobinemia (a blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Taking Dologel 15 gm with Phenytoin together can result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
LidocaineIopamidol
Severe
How does the drug interact with Dologel 15 gm:
Taking Dologel 15 gm and Iopamidol may increase the risk of causing seizures(fits).

How to manage the interaction:
Although taking Dologel 15 gm and Iopamidol together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Dologel 15 gm:
Taking Dologel 15 gm with phenobarbital may increase the risk of methemoglobinemia(blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking phenobarbital and Dologel 15 gm together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as grey discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dologel 15 gm:
Combining Sulfasalazine with Dologel 15 gm can increase the risk of methemoglobinemia (a rare red blood cell disorder in which too little oxygen is delivered to the cells).

How to manage the interaction:
Co-administration of Sulfasalazine with Dologel 15 gm can result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting a doctor.
LidocaineIohexol
Severe
How does the drug interact with Dologel 15 gm:
Taking Iohexol and Dologel 15 gm may increase the risk of causing seizures(fits).

How to manage the interaction:
Although there is a possible interaction between Dologel 15 gm and Iohexol, you can take these medicines together if prescribed by your doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
LidocaineMetrizamide
Severe
How does the drug interact with Dologel 15 gm:
Taking Dologel 15 gm and Metrizamide may increase the risk of causing seizures(fits).

How to manage the interaction:
Although taking Dologel 15 gm and Metrizamide together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Dologel 15 gm:
Coadministration of metoclopramide with Dologel 15 gm may increase the risk of methemoglobinemia(a blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although there is a possible interaction between metoclopramide and Dologel 15 gm, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as grey discolouration of the skin, nausea, headache, dizziness, weakness, breathing difficulty, rapid or shallow breathing, palpitation, anxiety, and confusion, consult a doctor. Do not stop using medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug Warnings

If you are allergic to Dologel or any other medicines, please tell your doctor. Dologel is for external use only. Avoid contact of Dologel with nose, ears, mouth or eyes. In case Dologel comes in contact with these areas accidentally, rinse with water thoroughly. If you are pregnant or a nursing mother, please inform your doctor before using Dologel. Avoid using Dologel in large amounts or for a long time than advised as it does not give quick or better results but increase the risk of side effects. 

Side Effects of Dologel

  • Itching or irritation at the site of application 

Directions for Use

Check the label for directions before using Dologel. Apply a sufficient amount of Dologel over the affected area. Wash your hands before and after use.

Medicinal Benefits Mweb

Medicinal Benefits

Dologel contains Benzalkonium chloride, Choline salicylate, and Lignocaine hydrochloride used to treat mouth ulcers. Benzalkonium chloride acts as an antibacterial agent and prevents secondary infections. Thus, it promotes the quick healing of mouth ulcers. Choline salicylate is a non-steroidal anti-inflammatory drug (NSAID) that blocks the action of cyclo-oxygenase (COX) enzyme in the body that is involved in the production of certain chemical substances such as prostaglandins that cause pain and swelling. Thereby, helps in relieving pain and swelling. Lignocaine hydrochloride is a local anesthetic that decreases pain sensation by preventing the transmission of pain signals from nerves to the brain. Also, Dologel is used to treat Oropharynx (middle part of the throat) inflammation.

Uses of Dologel

Mouth ulcers, Oropharynx (middle part of the throat) inflammation

About Dologel

Dologel belongs to a class of drugs called analgesics and antiseptics used in the treatment of mouth ulcers and oropharynx (middle part of the throat) inflammation. Mouth ulcers, also known as canker sores are small, painful lesions that develop in the mouth or at the base of the gums. These can make you uncomfortable while eating, drinking, and talking. They usually heal within a few weeks and are not contagious.

Dologel is a combination of three drugs, namely: Benzalkonium chloride (antibacterial agent), Choline salicylate (non-steroidal anti-inflammatory drug), and Lignocaine hydrochloride (local anesthetic). Benzalkonium chloride acts as an antibacterial agent and prevents secondary infections. Thus, it promotes the quick healing of mouth ulcers. Choline salicylate works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that is involved in the production of certain chemical substances such as prostaglandins that cause pain and swelling. Thereby, it helps in relieving pain and swelling. Lignocaine hydrochloride decreases pain sensation by preventing the transmission of pain signals from nerves to the brain.  

Dologel is for topical oral use only. You are advised to use Dologel for as long as your doctor has recommended it for you based on your condition. In some cases, you may experience itching or irritation at the site of the application. These side effects of Dologel do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. 

If you are allergic to Dologel or any other medicines, please tell your doctor. Avoid contact of Dologel with nose, ears, mouth, or eyes. In case Dologel comes in contact with these areas accidentally, rinse with water thoroughly. If you are pregnant or a nursing mother, please inform your doctor before using Dologel. Avoid using Dologel in large amounts or for a long time than advised as it does not give quick or better results but increases the risk of side effects. 

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Author Details

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Therapeutic Class

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